http://localhost:8080/xmlui/handle/123456789/364 Wed, 22 Apr 2026 17:43:13 GMT 2026-04-22T17:43:13Z http://localhost:8080/xmlui/handle/123456789/374 Cardiotoxicity of Anthracycline-based Chemotherapy in Breast Cancer Patients: A Case Series Tlegenova, Zh. Sh.; Balmagambetova, S. K.; Zholdin, B. K.; Kurmanalina, G. L.; Talipova, I. Zh.; Koyshybaev, A. K.; Sultanbekova, G. A.; Kubenova, K. I.; Baspayeva, M. B.; Madinova, S. S.; Amanova, A. In Kazakhstan, breast cancer (BC) remains the leading cause of cancer morbidity and mortality among women. The presented case series aims to summarize cardiovascular events that resulted in anthracycline-based chemotherapy discontinuation or suspension during the ongoing project on studying the cardiotoxicity effects. Case 1. Classic acute cardiotoxicity with asystole. Patient Sh., 46 years old, was admitted with a baseline LVEF of 64% and GLS of 22.4%. After the first dose of doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2, the patient experienced two episodes of asystole. She was prescribed Trimetazidine at a dose of 80 mg. Eventually, Sh. completed the courses of anthracycline therapy after a 1-month delay at a cumulative dose of 455 mg/m2. Case 2. Subacute cardiotoxicity with ventricular extrasystole. Patient Zh., aged 47, developed single, paired, and group ventricular extrasystoles after the 2nd course of chemotherapy with doxorubicin 200 mg/m2 (23 days after admission). Carvedilol was prescribed at 25 mg twice daily and Trimetazidine at 80 mg once a day. After 1 month of monitoring, ventricular extrasystoles disappeared. With a month’s delay, the patient completed chemotherapy at a cumulative dose of 400 mg/m2. Case 3. Severe cardiotoxicity due to pre-existing cardiovascular disease with discontinuation of chemotherapy. Patient M., aged 58, was referred to the very highrisk group for developed atrial fibrillation and heart failure with LVEF 51%. M. received Enalapril 5 mg two times per day, Bisoprolol 5 mg, Eplerenone 50 mg, Dapagliflozin 10 mg, and Dabigatran 150 mg twice daily. After 3 months, anthracycline therapy was canceled at a cumulative dose of 260 mg/m2 due to the deterioration of the patient’s condition (LVEF 41%.). Discontinuation or the delay of vitally needed chemotherapy in BC patients deteriorate their prognosis for survival. Patients should be constantly monitored during and after anticancer treatment. In Kazakhstan, breast cancer (BC) remains the leading cause of cancer morbidity and mortality among women. The presented case series aims to summarize cardiovascular events that resulted in anthracycline-based chemotherapy discontinuation or suspension during the ongoing project on studying the cardiotoxicity effects. Case 1. Classic acute cardiotoxicity with asystole. Patient Sh., 46 years old, was admitted with a baseline LVEF of 64% and GLS of 22.4%. After the first dose of doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2, the patient experienced two episodes of asystole. She was prescribed Trimetazidine at a dose of 80 mg. Eventually, Sh. completed the courses of anthracycline therapy after a 1-month delay at a cumulative dose of 455 mg/m2. Case 2. Subacute cardiotoxicity with ventricular extrasystole. Patient Zh., aged 47, developed single, paired, and group ventricular extrasystoles after the 2nd course of chemotherapy with doxorubicin 200 mg/m2 (23 days after admission). Carvedilol was prescribed at 25 mg twice daily and Trimetazidine at 80 mg once a day. After 1 month of monitoring, ventricular extrasystoles disappeared. With a month’s delay, the patient completed chemotherapy at a cumulative dose of 400 mg/m2. Case 3. Severe cardiotoxicity due to pre-existing cardiovascular disease with discontinuation of chemotherapy. Patient M., aged 58, was referred to the very highrisk group for developed atrial fibrillation and heart failure with LVEF 51%. M. received Enalapril 5 mg two times per day, Bisoprolol 5 mg, Eplerenone 50 mg, Dapagliflozin 10 mg, and Dabigatran 150 mg twice daily. After 3 months, anthracycline therapy was canceled at a cumulative dose of 260 mg/m2 due to the deterioration of the patient’s condition (LVEF 41%.). Discontinuation or the delay of vitally needed chemotherapy in BC patients deteriorate their prognosis for survival. Patients should be constantly monitored during and after anticancer treatment. Sun, 01 Jan 2023 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/374 2023-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/373 Empirical Nutrition Models and Their Impact on Public Health Khairullina, E.; Baspakova, A.; Zhumagaliyeva, S. This mini review delves into the transformative role of empirical nutrition models in the field of public health. By leveraging large-scale datasets and advanced statistical analyses, these models offer a more precise understanding of individual dietary needs, moving beyond traditional one-size-fits-all approaches. Their ability to identify and analyze complex dietary patterns, such as the Mediterranean diet or plant-based lifestyles, contributes to a more comprehensive assessment of overall dietary quality. Moreover, empirical nutrition models facilitate early intervention and prevention strategies by identifying risk factors for chronic diseases at an early stage. This proactive approach holds significant promise in reducing the burden of prevalent health issues, including obesity, diabetes, and cardiovascular disorders. The article also highlights the crucial role of these models in guiding policy development and influencing public health campaigns, providing evidence-based recommendations that address the diverse dietary needs of populations. Despite their promise, challenges such as data quality, standardization, and the dynamic nature of nutritional science are acknowledged. The abstract underscores the importance of continuous technological advancements and collaborative efforts among researchers, policymakers, and healthcare professionals to address these challenges and refine the accuracy of nutrition models. In conclusion, empirical nutrition models represent a paradigm shift toward more personalized and effective public health strategies. As these models continue to evolve with technological advancements, their impact on public health is poised to grow. They can contribute to creating healthier communities and foster a more nuanced understanding of the complex relationship between diet and overall well-being. This mini review delves into the transformative role of empirical nutrition models in the field of public health. By leveraging large-scale datasets and advanced statistical analyses, these models offer a more precise understanding of individual dietary needs, moving beyond traditional one-size-fits-all approaches. Their ability to identify and analyze complex dietary patterns, such as the Mediterranean diet or plant-based lifestyles, contributes to a more comprehensive assessment of overall dietary quality. Moreover, empirical nutrition models facilitate early intervention and prevention strategies by identifying risk factors for chronic diseases at an early stage. This proactive approach holds significant promise in reducing the burden of prevalent health issues, including obesity, diabetes, and cardiovascular disorders. The article also highlights the crucial role of these models in guiding policy development and influencing public health campaigns, providing evidence-based recommendations that address the diverse dietary needs of populations. Despite their promise, challenges such as data quality, standardization, and the dynamic nature of nutritional science are acknowledged. The abstract underscores the importance of continuous technological advancements and collaborative efforts among researchers, policymakers, and healthcare professionals to address these challenges and refine the accuracy of nutrition models. In conclusion, empirical nutrition models represent a paradigm shift toward more personalized and effective public health strategies. As these models continue to evolve with technological advancements, their impact on public health is poised to grow. They can contribute to creating healthier communities and foster a more nuanced understanding of the complex relationship between diet and overall well-being. Sun, 01 Jan 2023 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/373 2023-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/372 Long-term Results of Optical Laser Urethrotomy for Post-traumatic Stricture of the Membranous Urethra Nurberdiev, A.; Suchshenko, A.; Kazhitaev, A.M.; Zhanbyrbekuly, U.; Khairli, G. Urethral stricture is a common condition characterized by the narrowing of the urethra, leading to difficulty in urination. This article presents a case report of a 47-yearold male with urethral stricture following a pelvic fracture. The patient presented with urinary retention and a history of traumatic injury. Diagnostic imaging revealed a 2.0-2.2 cm stricture in the membranous urethra. Surgical intervention, including optical laser urethrotomy and silicone urethral catheter placement, was performed successfully. Postoperative management included antibacterial and anti-inflammatory therapy, leading to the restoration of independent urination. Urodynamic examination confirmed the successful outcome of the surgery. This case demonstrates that endoscopic surgery for urethral strictures can have a favorable prognosis. However, due to the potential for recurrence, ongoing outpatient care and monitoring by a urologist are essential for these patients. Urethral stricture is a common condition characterized by the narrowing of the urethra, leading to difficulty in urination. This article presents a case report of a 47-yearold male with urethral stricture following a pelvic fracture. The patient presented with urinary retention and a history of traumatic injury. Diagnostic imaging revealed a 2.0-2.2 cm stricture in the membranous urethra. Surgical intervention, including optical laser urethrotomy and silicone urethral catheter placement, was performed successfully. Postoperative management included antibacterial and anti-inflammatory therapy, leading to the restoration of independent urination. Urodynamic examination confirmed the successful outcome of the surgery. This case demonstrates that endoscopic surgery for urethral strictures can have a favorable prognosis. However, due to the potential for recurrence, ongoing outpatient care and monitoring by a urologist are essential for these patients. Sun, 01 Jan 2023 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/372 2023-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/371 Mesenchymal Stem Cell Therapy for Azoospermia: Navigating Differentiation Challenges and Charting Future Frontiers in Male Fertility Treatment Rahmanifar, F. This minireview explores the current landscape of stem cell therapy for azoospermia, focusing on the potential and challenges associated with Mesenchymal Stem Cells (MSCs). The discussion encompasses the precise regulation of MSC differentiation, safety considerations, and ethical implications. Recent advancements in optimizing differentiation protocols, improving engraftment efficiency, and ongoing clinical trials are highlighted. Despite the hurdles, MSCs emerge as a promising avenue for male infertility treatment. The conclusion emphasizes the necessity for continued research and clinical trials to unlock the full potential of MSC therapy in addressing the complexities of azoospermia. This minireview explores the current landscape of stem cell therapy for azoospermia, focusing on the potential and challenges associated with Mesenchymal Stem Cells (MSCs). The discussion encompasses the precise regulation of MSC differentiation, safety considerations, and ethical implications. Recent advancements in optimizing differentiation protocols, improving engraftment efficiency, and ongoing clinical trials are highlighted. Despite the hurdles, MSCs emerge as a promising avenue for male infertility treatment. The conclusion emphasizes the necessity for continued research and clinical trials to unlock the full potential of MSC therapy in addressing the complexities of azoospermia. Sun, 01 Jan 2023 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/371 2023-01-01T00:00:00Z