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dc.contributor.author Mobarak, H.
dc.contributor.author Rahbarghazi, R.
dc.contributor.author Mahdipour, M.
dc.date.accessioned 2024-06-13T06:30:15Z
dc.date.available 2024-06-13T06:30:15Z
dc.date.issued 2023
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/358
dc.description The efficiency of stem cell (SC)-based therapies has been proven in numerous animal and human studies. Along with the differentiation into several lineages, it is quite evident that SCs convey significant therapeutic effects in a paracrine manner via releasing various nano-sized extracellular vesicles (EVs) containing cytokines and bioactive factors. Notably, recent trials have stated the lack of stability and durability of the transplanted SCs at the site of injury for long periods, leading to the restrictions of SC in regenerative outcomes. Thus, EVs especially exosomes (Exos) gained much attention for therapeutic purposes and delivery purposes to the injury site. In contrast to whole-SC-based therapies, Exos can be used with fewer side effects. However, it should not be forgotten that both whole-SC- and cell-free-based options possess inherent pros and cons that necessitate being carefully evaluated before application in the clinical setting. Here, the effectiveness and limitations associated with whole-SCand SC-free-based therapies in the clinical setting are briefly discussed. ru
dc.description.abstract The efficiency of stem cell (SC)-based therapies has been proven in numerous animal and human studies. Along with the differentiation into several lineages, it is quite evident that SCs convey significant therapeutic effects in a paracrine manner via releasing various nano-sized extracellular vesicles (EVs) containing cytokines and bioactive factors. Notably, recent trials have stated the lack of stability and durability of the transplanted SCs at the site of injury for long periods, leading to the restrictions of SC in regenerative outcomes. Thus, EVs especially exosomes (Exos) gained much attention for therapeutic purposes and delivery purposes to the injury site. In contrast to whole-SC-based therapies, Exos can be used with fewer side effects. However, it should not be forgotten that both whole-SC- and cell-free-based options possess inherent pros and cons that necessitate being carefully evaluated before application in the clinical setting. Here, the effectiveness and limitations associated with whole-SCand SC-free-based therapies in the clinical setting are briefly discussed. ru
dc.language.iso en ru
dc.publisher West Kazakhstan Medical Journal ru
dc.subject stem cell transplantation ru
dc.subject cell-free system ru
dc.subject exosomes ru
dc.subject regenerative medicine ru
dc.subject immune evasion ru
dc.title Stem Cell- and Stem Cell-Free-Based Therapies: Pros and Cons ru
dc.type Article ru


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