New slant on hypolipidemic characteristics of vitamin-E and red date

Abstract

Background: High plasma lipids can cause complications leading to development of metabolic syndrome, including hypercholesterolemia, hypertension and hyperglycemia. To treat syndrome by allopathic regimn of allopathic drugs is difficult to treat. Herbal medicine are replacing drug treatment of hyperglycemia, hypertension and hyperlipidemia especially by antioxidant effects of their active ingredients. We have compared antioxident characteristics of vitamin-E and red Dates. Type/place/duration of Study: It was placebo-controlled conducted study conducted at general hospital Lahore Pakistan from January 2014 to march 2014. Inclusion and exclusion criteria: 120 male hyperlipidemic patients were included with age range from 18 to 70 years. We excluded patients already suffering from renal, hepatic, pulmonary, or thyroid diseases. We also excluded patients already on cardio and hepato-protective drugs. Sample size and division of patients: 120 hyperlipidemic patients were divided in three equal number of patients, 40 patients in each group. Group-I (n=40) was on placebo. They were provided capsules which were filled with grounded brown rice taking 8 hourly daily for one month. Group-II (n=40) was on capsules of vitamin E 400 mg taking eight hourly daily for one month. Group-II (n=40) was advised to take red dates 20 grams thrice daily for the period of one month. Method of lipid profile determination: LDL-cholesterol was calculated as total cholesterol- HDL cholesterol-VLDL-cholesterol;VLDL-cholesterol was measured directly after ultracentrifugation. Observations and Results: After one month therapy their post treatment lipid profile was determined and analyzed statistically by using SPSS version 2.2.01 2013. Paired ‘t’ test was applied for mean values with SD of the parameters before and after treatment. Results showed highly significant change in LDL-cholesterol of group-II patients but HDL-cholesterol was increased 6.6 mg/dl, still it was significant change with p-value of <0.01. In group-III LDL-cholesterol was decreased 10.9 mg/dl which is significant change with p-value <0.01. HDL-cholesterol in this group was increased 4.2 mg/dl which is non significant with p-value of >0.05. Conclusion: We concluded from the study that Z. Jujube has antioxidant potential by lowering LDL-cholesterol in human plasma. But This effect is not comparable with hypolipidemic effects of Vitamin E as it also increases good cholesterol i.e. HDL-cholesterol.