Abstract:
Parkinson’s disease (PD) is the second most common neurodegenerative disorder
worldwide, with an annual incidence of 8–18 per 100,000 individuals. Its prevalence
rises significantly in populations aged 60 and older, with cases projected to double
by 2030. While amantadine is well-recognized for managing dyskinesia and as initial
monotherapy in PD, its utility in addressing PD decompensation remains insufficiently
studied.
This report details the case of a 72-year-old Asian woman with PD who developed
bilateral lower lobe pneumonia with a prolonged fever. Her condition was marked by
worsening motor symptoms, including increased rigidity and tremors. An intravenous
infusion of amantadine sulfate was administered, resulting in notable improvements
in muscle tone, rigidity, and tremor control. This case highlights the potential role of
amantadine in stabilizing motor function during acute systemic stress, such as severe
infections.
The findings suggest that amantadine sulfate may serve as an effective therapeutic
option for PD decompensation in complex clinical scenarios involving comorbid
conditions. This case underscores the need for further investigation to define the
therapeutic range and establish targeted treatment protocols for PD patients requiring
critical care interventions.
Description:
Parkinson’s disease (PD) is the second most common neurodegenerative disorder
worldwide, with an annual incidence of 8–18 per 100,000 individuals. Its prevalence
rises significantly in populations aged 60 and older, with cases projected to double
by 2030. While amantadine is well-recognized for managing dyskinesia and as initial
monotherapy in PD, its utility in addressing PD decompensation remains insufficiently
studied.
This report details the case of a 72-year-old Asian woman with PD who developed
bilateral lower lobe pneumonia with a prolonged fever. Her condition was marked by
worsening motor symptoms, including increased rigidity and tremors. An intravenous
infusion of amantadine sulfate was administered, resulting in notable improvements
in muscle tone, rigidity, and tremor control. This case highlights the potential role of
amantadine in stabilizing motor function during acute systemic stress, such as severe
infections.
The findings suggest that amantadine sulfate may serve as an effective therapeutic
option for PD decompensation in complex clinical scenarios involving comorbid
conditions. This case underscores the need for further investigation to define the
therapeutic range and establish targeted treatment protocols for PD patients requiring
critical care interventions.
