Abstract:
Conclusions: Thus, there is no doubt about the presence of immune mechanisms in
children with pyelonephritis on congenital hydronephrosis background, autoimmune
syndrome is developed by damage of own cells membranes and sensitization to cell
components mimicking the infectious agent antigens. Post-infectious autoimmune
syndrome in combination with secondary immunodeficiency is a more severe condition
because involves not only autoaggression, but also a lack of factors and components
of immune response, manifested by severe course of pyelonephritis in children
with congenital hydronephrosis. The existing immunodeficiency creates conditions
for disease progression, stimulates other pathogenetic factors, and as the infectious
inflammatory process is developing, an immunological insufficiency is worsening and
associated not only with the persistence of microorganisms, their toxins, but also with
depletion of immune system reserves.
Description:
Conclusions: Thus, there is no doubt about the presence of immune mechanisms in
children with pyelonephritis on congenital hydronephrosis background, autoimmune
syndrome is developed by damage of own cells membranes and sensitization to cell
components mimicking the infectious agent antigens. Post-infectious autoimmune
syndrome in combination with secondary immunodeficiency is a more severe condition
because involves not only autoaggression, but also a lack of factors and components
of immune response, manifested by severe course of pyelonephritis in children
with congenital hydronephrosis. The existing immunodeficiency creates conditions
for disease progression, stimulates other pathogenetic factors, and as the infectious
inflammatory process is developing, an immunological insufficiency is worsening and
associated not only with the persistence of microorganisms, their toxins, but also with
depletion of immune system reserves.
