INNATE AND ADAPTIVE IMMUNITY STATE DETERMINATION IN CHILDREN WITH PYELONEPHRITIS ON CONGENITAL HYDRONEPHROSIS BACKGROUND IN ACTIVE STAGE OF THE DISEASE

Abstract

Conclusions: Thus, there is no doubt about the presence of immune mechanisms in children with pyelonephritis on congenital hydronephrosis background, autoimmune syndrome is developed by damage of own cells membranes and sensitization to cell components mimicking the infectious agent antigens. Post-infectious autoimmune syndrome in combination with secondary immunodeficiency is a more severe condition because involves not only autoaggression, but also a lack of factors and components of immune response, manifested by severe course of pyelonephritis in children with congenital hydronephrosis. The existing immunodeficiency creates conditions for disease progression, stimulates other pathogenetic factors, and as the infectious inflammatory process is developing, an immunological insufficiency is worsening and associated not only with the persistence of microorganisms, their toxins, but also with depletion of immune system reserves.